Compulsion turns off satiety

  •  August 13, 2020


Compulsion turns off satiety

It sounds ironic, but seeing the body round can be the result of a circle - vicious. Study proves how overeating turns off brain satiety sensors, which makes you forget you ate and want to eat more.

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There are some factors that lead to overweight and obesity, such as genetics and physical inactivity.


But the best known is certainly overeating.

The subject is viewed with great uncertainty, as the notion of moderation varies from person to person.

The truth is that overeating at the table is occasionally seen very naturally.


The sensation is known, especially at family lunches, when your favorite dish is served.

And then you eat until you can't take it anymore, when satiety signals prevent you from a last bite.

This feeling is triggered by various hormones, such as leptin, that flow into the digestive tract.


However, a study by Thomas Jefferson University found that overeating can disrupt sensitivity to these hormones.

In previous studies, researchers observed that uroguaniline hormone may be involved with weight gain.

In experiments on guinea pigs, normal-weight animals revealed the transit of uroguanylin to the brain, where it helped to produce the feeling of satiety.

In obese animals, however, this signal system has proven to be flawed.

To better understand the mechanism, Dr. Scott Waldman and his team performed new experiments using guinea pigs.

When the animals were overfed, the scientists observed the interruption of uroguanylin signals.

Upon examination of the guinea pig's intestines, it was found that uroguaniline was no longer being secreted.

Their brains still had hormone receptors, which even increased their concentration.

This means that the interruption of the signals was caused by the side of uroguaniline, which was no longer produced.

When animals were put on diet, hormone secretion was normalized.

With the guinea pig's small intestine under the microscope, scientists have discovered the root cause of the problem in the endoplasmic reticulum (RE), a network between cells that is responsible for creating proteins and hormones.

If RE is under stress, such as when we eat too much, it stops working.

According to Dr. Waldman, the study shows that too many calories stress small intestine cells, which stop producing uroguaniline, confusing satiety signals.

"What we don't know yet is how much (food) is too much."

“And which molecular sensor is responsible for making the decision (to stop hormone production),” concluded Dr. Waldman - as quoted by the website. Science daily.

"We don't know yet if this is important at the beginning of the process, or later, and how representative of the role it plays."

"But in combination with other approaches, uroguanylin hormone replacement can become an important component of therapy to reduce obesity."

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